Procuct Name:Niclosamide 50% WP

CAS No.: 50-65-7

Description: 

Niclosamide

Molluscicide

NOMENCLATURE

Common name niclosamide (BSI, E-ISO, (m) F-ISO, BAN, Germany (for veterinary use))

IUPAC name 2’,5-dichloro-4’-nitrosalicylanilide 

Chemical Abstracts name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide 

CAS RN [50-65-7]

PHYSICAL CHEMISTRY

Mol. wt. 327.1

M.f. C13H8Cl2N2O4

Form Almost colourless crystals.

M.p. 230 ºC

V.p. <1 mPa (20 ºC)

KOW logP = 1 (pH 9.6)

Solubility In water 1.6 (pH 6.4), 110 (pH 9.1) (both in mg/l, 20 ºC). Soluble in common organic solvents such as ethanol and diethyl ether.

Stability Hydrolysed in aqueous solution, DT50 (20 ºC) c. 7 d (pH 6.9), 18.8 d (pH 13.3). Stable to heat. Decomposes under u.v. irradiation. Hydrolysed by concentrated acid or alkali. 

APPLICATIONS

Mode of action Molluscicide with respiratory and stomach action.

Uses Control of golden apple snail in rice. Control of schistosomiasis and fascioliasis in man by killing fresh-water snails which act as intermediate hosts. Also used for veterinary control of tapeworm infestations.

Selected tradenames: ’Bayluscide’ (EC250) (Bayer) Formulation types WP.