Procuct Name:Niclosamide 25% SC

CAS No.: 50-65-7

Description: 

Niclosamide

Molluscicide

OMENCLATURE

niclosamide

Common name niclosamide (BSI, E-ISO, (m) F-ISO, BAN, Germany (for veterinary use))

IUPAC name 2’,5-dichloro-4’-nitrosalicylanilide 

Chemical Abstracts name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide 

CAS RN [50-65-7]

niclosamide-olamine

Common name niclosamide-olamine (BSI, E-ISO, (m) F-ISO, BAN); clonitralid (Germany, for public health use)

CAS RN [1420-04-8]

PHYSICAL CHEMISTRY

niclosamide

Mol. wt. 327.1

M.f. C13H8Cl2N2O4

Form Almost colourless crystals.

M.p. 230 ºC

V.p. <1 mPa (20 ºC)

KOW logP = 1 (pH 9.6)

Solubility In water 1.6 (pH 6.4), 110 (pH 9.1) (both in mg/l, 20 ºC). Soluble in common organic solvents such as ethanol and diethyl ether.

Stability Hydrolysed in aqueous solution, DT50 (20 ºC) c. 7 d (pH 6.9), 18.8 d (pH 13.3). Stable to heat. Decomposes under u.v. irradiation. Hydrolysed by concentrated acid or alkali. 

niclosamide-olamine

Mol. wt. 388.2

M.f. C15H15Cl2N3O5

Form Yellow, crystalline solid.

M.p. Decomposes at 208 ºC

V.p. <<1 mPa (20 °C)

Solubility In water 0.1 g/l (20 ºC). In n-hexane, toluene <0.1, dichloromethane 0.015, isopropanol 0.25 (all in g/l, 20 ºC). 

APPLICATIONS

Mode of action Molluscicide with respiratory and stomach action.

Uses Control of golden apple snail in rice. Control of schistosomiasis and fascioliasis in man by killing fresh-water snails which act as intermediate hosts. Also used for veterinary control of tapeworm infestations.

niclosamide

Compatibility Incompatible with acidic materials.

Selected tradenames: ’Bayluscide’ (EC250)  Formulation types WP. 

niclosamide-olamine

Selected tradenames: ’Bayluscide’ (WP70)